Welcome to gene discovery lab !
 
   Publications
  1. Yan Jiao, Xiudong Jin, Jian Yan, Chi Zhang, Feng Jiao, Xinmin Li, Bruce A. Roe, David B. Mount, Weikuan Gu. A deletion mutation in Slc12a6 is associated with neuromuscular disease in gaxp mice . Genomics. 2008 Mar 13; [Epub ahead of print] PMID: 18343091
  2. Qing Xiong, Yuhui Qiu, Weikuan Gu. PGMapper: a web-based tool linking phenotype to genes . Bioinformatics. 2008 Apr 1; 24(7):1011-3.
  3. Yan Jiao, Jian Yan, Feng Jiao, HongBin Yang, Leah Rae Donahue, Xinmin Li, Bruce A. Roe, John Stuart, Weikuan Gu. A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice. BMC Genet. 2007 Apr 17;8(1):16 [Epub ahead of print]
  4. Yan Jiao, Hank Chiu,  Zaifeng Fan, Feng Jiao,  Eugene C. Eckstein , Wesley G. Beamer, Weikuan Gu. Quantitative Trait Loci that Determine Mouse Tibial Nanoindentation Properties in an F(2) Population Derived from C57BL/6J X C3H/HeJ.  Calcif Tissue Int. 2007 Jun 7; [Epub ahead of print]
  5. Jian Yan   Weikuan Gu.  Parameters of Quantitative Trait Loci.  Critical Reviews™ in Eukaryotic Gene Expression. 2007;17(4):335-346
  6. Jian Yan , Yan Jiao,  Xinmin Li, Feng Jiao,  Wesley G. Beamer, Cliff J. Rosen, Weikuan Gu. Evaluation of gene expression profiling in a mouse model of L-gulonolactone oxidase gene deficiency. Genetics and Molecular Biology. Genetics and Molecular Biology, 30, 2, 322-329 (2007).
  7. Jian Yan, Yan Jiao, Feng Jiao, John Stuart, Leah Rae Donahue, Wesley G. Beamer, Xinmin Li, Bruce A. Roe, Mark S. LeDoux, Weikuan Gu. Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse. Neurosci Lett. 2007 Feb 21;413(3):196-201. Epub 2006 Dec 15.
  8. Yan Jiao, Jian Yan, Yu Zhao, Leah Rae Donahue, Wesley G. Beamer, Xinmin Li, Bruce A. Roe, Mark S. LeDoux, Weikuan Gu. Carbonic anhydrase-related protein VIII deficiency is associated with a distinctive lifelong gait disorder in waddles mice. Genetics. 2005; Nov;171(3):1239-46. Epub 2005 Aug 22.
  9. Li XM, Kim J, Zhou J, Gu WK, Dyanov H and Quigg R. Use of signal thresholds to determine significant changes in microarray data analyses.  Genetics and Molecular Biology.  2005; 28(2): 191-200.
  10. Jiao Y, Li XM, Beamer WG, Yan J, Tong Y, Goldowitz D, Roe B, Gu WK. Identification of a deletion causing spontaneous fracture by screening a candidate region of mouse chromosome 14. Mammalian Genome.  2005; 16(1):20-31.
  11. The Complex Trait Consortium. Gary A Churchill et al.  The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics Volume 36 | Number 11 | November 2004 3
  12. Biola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittlemann G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, Zou F; Complex Trait Consortium.  The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet. 2003 Nov;4(11):911-6.
  13. Brooks MB, Gu W, Barnas JL, Ray J, Ray K. A Line 1 insertion in the Factor IX gene segregates with mild hemophilia B in dogs. Mammalian Genome 2003;14:788-795.
  14. Gu W-K.,  X-M. Li, B. A. Roe, K-H. William Lau, B. Edderkaoui, S. Mohan and D. J. Baylink.  Application of Genomic Resources and Gene Expression Profiles to Identify Genes That Regulate Bone Density. Current Genomics 2003, 4, 75-102.
  15. Masinde GL, Li X, Gu W, Wergedal J, Mohan S, Baylink DJ. Quantitative trait loci for bone density in mice: the genes determining total skeletal density and femur density show little overlap in F2 mice. Calcif Tissue Int. 2002 Nov;71(5):421-8.
  16. Li X, Srivastava AK, Gu W, Masinde G, Mohan S, Baylink DJ. Opposing changes in osteocalcin levels in bone vs serum during the acquisition of peak bone density in C3H/HeJ and C57BL/6J mice.  Calcif Tissue Int. 2002 Aug 13
  17. Li X, Gu W, Mohan S, Baylink DJ. DNA microarrays: their use and misuse. Microcirculation. 2002 Jan;9(1):13-22.
  18. Li X, Masinde G, Gu W, Wergedal J, Mohan S, Baylink DJ. Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 Mice: single QTL effects, epistasis, and pleiotropy. Genomics. 2002 May;79(5):734-40.
  19. Gu WK, Li XM, Edderkaoui B, Strong DD, Lau KH, Beamer WG, Donahue LR, Mohan S, Baylink DJ. Construction of a BAC contig for a 3 cM biologically significant region of mouse chromosome 1. Genetica. 2002;114(1):1-9.
  20. Gu W, Li X, Lau KH, Edderkaoui B, Donahae LR, Rosen CJ, Beamer WG, Shultz KL, Srivastava A, Mohan S, Baylink DJ. Gene expression between a congenic strain that contains a quantitative trait locus of high bone density from CAST/EiJ and its wild-type strain C57BL/6J. Funct Integr Genomics. 2002 Apr;1(6):375-86.
  21. Li X, Masinde G, Gu W, Wergedal J, Hamilton-Ulland M, Xu S, Mohan S, Baylink DJ. Chromosomal regions harboring genes for the work to femur failure in mice. Funct Integr Genomics. 2002 Apr;1(6):367-74.
  22. Xinmin Li, Gu W-K., Masinde G., S. Xu, S. Mohan, D. J Baylink (2001) Genetic control of the rate of wound healing in mice. Heredity 86:668-674.
  23. Li X., Mohan S., Gu W-K, and Baylink D.J. (2001) Analysis of gene expression in the wound repair/regeneration process. Mammalian Genome. 12:52-59.
  24. Li X, Gu W, Masinde G, Hamilton-Ulland M, Rundle CH, Mohan S, Baylink DJ. (2001) Genetic variation in bone-regenerative capacity among inbred strains of mice. Bone. 29(2) 134-140.
  25. X. Li, Mohan S., Gu W-K., Wergedal J.,  & Baylink D.J. (2001) Quantitative Assessment of Forearm Muscle Size, Forelimb Grip Strength, Forearm Bone Mineral Density, and Forearm Bone Size in Determining Humerus Breaking Strength in 10 Inbred Strains of Mice . Calcified Tissue International. 68:365-369.
  26. Beamer W.G., Rosen C.J., Bronson R.T., Gu W-K, Donahue L.R., Baylink D.J., Richardson C.C., Crawford G.C., Barker J.E. (2000) Spontaneous fracture (sfx): a mouse genetic model of defective peripubertal bone formation. Bone. 27(5):619-626.
  27. Li  X., Mohan S., Gu W-K, Miyakoshi N. and Baylink D.J. (2000) Differential Protein Profile in the Ear-punched Tissue of Regeneration and Non-regeneration Strains of Mice: A Novel Approach to Explore the Candidate Genes for Soft-tissue Regeneration. Biochimica et Biophysica Acta. 1524 (2000):102-109.
  28. Gu, W-K,  Brooks M., Catalfamo J., Ray J., and Ray K. (1999).  Two distinct mutations cause severe hemophilia B in two unrelated canine pedigrees. Thromb Haemost 82:1270-1275.
  29. Gu, W-K, Ray, K. , Pearce-Kelling, S., Baldwin, V. J., Langston, A. A.,  Ray, J., Ostrander, E., Acland, G. M.,  and Aguirre G. D.  (1999).  Evaluation of the APOH gene as a positional candidate for prcd in dogs.  Inv. Ophthalm.    Vis. Sci.40:1229-1237.
  30. Gu, W-K, Post, C., Aguirre, G. D., and Ray K. (1999).  Individual DNA bands obtained by RAPD analysis of canine genomic DNA often contain multiple DNA sequences. J. Heredity. 90:96-98.
  31. Gu, W-K,  Acland, G. M., Langston, A. A. Ostrander, E. A., Aguirre, G. D.,  and Ray, K. (1998). Identification of a RAPD marker linked to progressive rod-cone degeneration in dogs. Mammalian Genome. 9:740-744.
  32. Gu, W-K, Zhu, J., Wallace, D. H., Singh, S., and Weeden, N. F.  (1998). Analysis of genes controlling photoperiod sensitivity in common bean using DNA markers . Euphytica.  102:125-132.
  33. Gu, W-K, Aguirre, G. D., and K. Ray, K.   (1998).  Detection of single nucleotide    polymorphisms. BioTechniques. 24:836-837.
  34. Acland, G. M., Ray, K., Mellersh, C. S., Gu, W-K, Langston, , A. A. , Rine, J. ,Ostrander, E. A. and Aguirre, G. D.  (1998). Linkage analysis and comparative mapping of canine progressive rod-cone degeneration (prcd) establishes potential locus homology with retinitis pigmentosa (RP17) in humans.  Proc Natl Acad Sci U S A  95:3048-3053.
  35. Brooks, M., Gu, W-K, and Ray. K. (1997). Complete deletion of factor IX gene and inhibition of factor IX activity in a labrador retriever with hemophilia B.  Journal of the American Veterinary Medicine Association 211(11):1418-1421.
  36. Gu, W-K.,. Acland, G. M. , Aguirre, G. D. and Ray, K.  (1997). Evaluation of RAPD analysis for identification of polymorphisms in canine genomic DNA.  Animal Biotechnology 8(2):207-219.
  37. Gu, W-K and Ray, K.  (1997).  A polymorphic (TTTA)n tandem repeat in an intron of the canine factor IX gene.  Animal Genetics 28:370.